Laboratory for Animal Model Pathology (LAMP)

The Laboratory for Animal Model Pathology (LAMP) has been established to assist research in relevant, generic areas of laboratory/experimental animal morphology and pathology.

a core research and service facility at the Vetsuisse Faculty, University of Zurich.

technical services and expertise to researchers at the University of Zurich and outside clients who undertake morphological studies as part of their work with animal models and/or laboratory animals.

Submisson Form LAMP

foster interdisciplinary research for optimal use of laboratory/experimental animals;

provide scientific support through laboratory animal health monitoring and disease diagnosis (diagnostic service);

provide veterinary pathology expertise for research projects involving animal work (on collaborative and service basis);

provide a timely and cost-effective technical service and expertise in relevant, generic areas of laboratory/experimental animal morphology and pathology;

train researchers in basic techniques to allow optimal in situ studies on experimental animals (in collaboration with the Institute of Laboratory Animal Science LAS/LTK, Vetsuisse Faculty, University of Zürich: www.ltk.uzh.ch).

Veterinary pathologists at LAMP are partners in various interdisciplinary research projects and lead their own laboratory animal research tracks. Find further information on our research site under Animal Models. For a list of selected recent publications, see below.

Yustina M P, Stefano M, Jiaying H, Caroline K, Francesco P, Luca L, Susan B, Alexander A, Fabrizio M, Jürg H B, Thomas F L, Dario B, Giovanni G C, 2024, Hutchinson-Gilford progeria syndrome mice display accelerated arterial thrombus formation and increased platelet reactivity. Thromb Res. 2024 Sep:241:109100.  doi: 10.1016/j.thromres.2024.109100. Epub 2024 Jul 18.

Lisa P, Tanja RJ, Matteo R, Giorgio G, Martina P, Benedetta DPC, Frauke S, Julia H, Dorothee V, Simone G, Fabio G, 2024, Protection from environmental enteric dysfunction and growth improvement in malnourished newborns by amplification of secretory IgA. Cell Rep Med. 2024 Jul 16;5(7):101639.  doi: 10.1016/j.xcrm.2024.101639. Epub 2024 Jul 2.

Irma T, Carmen S M Y, Lisa K, Irene V, Sabrina R, Alba SF, Hung-Wei C, Rona W, Matthias G, Anja K, Burkhard L, Martin P, 2024, Delayed tumor-draining lymph node irradiation preserves the efficacy of combined radiotherapy and immune checkpoint blockade in models of metastatic disease. Nat Commun. 2024 Jun 29;15(1):5500.  doi: 10.1038/s41467-024-49873-y.

Madsen S, Delgado AC, Cadilhac C, Maillard V, Battiston F, Igelbüscher CM, De Neck S, Magrinelli E, Jabaudon D, Telley L, Doetsch F, Knobloch M, 2024, A fluorescent perilipin 2 knock-in mouse model reveals a high abundance of lipid droplets in the developing and adult brain. Nat Commun. 2024 Jun 28;15(1):5489. doi: 10.1038/s41467-024-49449-w.

Thomson BR, Schwendinger N, Beckmann K, Gentinetta T, Couto D, Wymann S, Verdon V, Buzzi RM, Akeret K, Kronen PW, Weinberger EM, Held U, Seehusen F, Richter H, Schaer DJ, Hugelshofer M, 2024, Haptoglobin Attenuates Cerebrospinal Fluid Hemoglobin-Induced Neurological Deterioration in Sheep. Transl Stroke Res. 2024 Apr 23. doi: 10.1007/s12975-024-01254-9. Online ahead of print.

Rotta G, Gilardoni E, Ravazza D, Mock J, Seehusen F, Elsayed A, Puca E, De Luca R, Pellegrino C, Look T, Weiss T, Manz MG, Halin C, Neri D, Dakhel Plaza S, 2024, A novel strategy to generate immunocytokines with activity-on-demand using small molecule inhibitors. EMBO Mol Med. 2024 Apr;16(4):904-926.  doi: 10.1038/s44321-024-00034-0. Epub 2024 Mar 6. 

Feuerriegel GC, Marth AA, Goller SS, Hilbe M, Sommer S, Sutter R, Quantifying Tendon Degeneration Using Magic Angle Insensitive Ultra-Short Echo Time Magnetization Transfer: A Phantom Study in Bovine Tendons. Invest Radiol. 2024 Oct 1;59(10):691-698.  doi: 10.1097/RLI.0000000000001074. Epub 2024 Apr 10.

Kang Y, Hepojoki J, Maldonado RS, Mito T, Terzioglu M, Manninen T, Kant R, Singh S, Othman A, Verma R, Uusimaa J, Wartiovaara K, Kareinen L, Zamboni N, Nyman TA, Paetau A, Kipar A, Vapalahti O, Suomalainen A, 2024, Ancestral allele of DNA polymerase gamma modifies antiviral tolerance. Nature. 2024 Apr;628(8009):844-853. doi: 10.1038/s41586-024-07260-z. Epub 2024 Apr 3.

Zhuang X, Gallo G, Sharma P, Ha J, Magri A, Borrmann H, Harris JM, Tsukuda S, Bentley E, Kirby A, de Neck S, Yang H, Balfe P, Wing PAC, Matthews D, Harris AL, Kipar A, Stewart JP, Bailey D, McKeating JA, 2024, Hypoxia inducible factors inhibit respiratory syncytial virus infection by modulation of nucleolin expression. iScience​​​​​​​. 2023 Dec 18;27(1):108763. doi: 10.1016/j.isci.2023.108763. eCollection 2024 Jan 19.

Freitag LF, Andersson LC, Kipar A, 2024, Concerns about the histological assessment in a mouse model of human celiac disease, Scandinavian Journal of ImmunologyVolume 99, Issue 3.  doi.org/10.1111/sji.13351

Emmert MY, Burrello J, Wolint P, Hilbe M, Andriolo G, Balbi C, Provasi E, Turchetto L, Radrizzani M, Nazari-Shafti TZ, Cesarovic N, Neuber S, Falk V, Hoerstrup SP, Hemetsberger R, Gyöngyösi M, Barile L, Vassalli G, 2024, Intracoronary delivery of extracellular vesicles from human cardiac progenitor cells reduces infarct size in porcine acute myocardial infarction. Eur Heart J​​​​​​​. 2024 Mar 1;45(9):728-732. doi: 10.1093/eurheartj/ehad636.

Yassini N, Sprenger J, Pastor Arroyo EM, Krudewig C, Pellegrini G, Joller N, Wagner CA, Imenez Silva PH, Ovarian cancer G protein-coupled receptor 1 deficiency exacerbates crystal deposition and kidney injury in oxalate nephropathy in female mice. Clin Sci (Lond)​​​​​​​. 2023 Jul 31;137(14):1013-1025. doi: 10.1042/CS20230421.

Han X, Clark JJ, Sharma P, Bentley EG, Kipar A, Alsayer M, Ren X, Robinson A, Alaidarous S, Mu Y, Sun Y, Hiscox JA, Zhou EM, Stewart JP, Zhao Q, 2024, Amino acids 1811-1960 of myosin heavy chain 9 is involved in murine gammaherpesvirus 68 infection. Virology​​​​​​​. 2023 Oct:587:109849. doi: 10.1016/j.virol.2023.109849. Epub 2023 Jul 24.

Devaud YR, Avilla-Royo E, Lionetti L, Tronnier H, Seehusen F, Monné Rodriguez JM, Moehrlen U, Weisskopf M, Vonzun L, Strübing N, Ochsenbein-Kölble N, Ehrbar M, 2023, Tissue Glue-Based Sealing Patch for the in vivo Prevention of Iatrogenic Prelabor Preterm Rupture of Fetal Membrane. Fetal Diagn Ther. 2023;50(5):332-343. doi: 10.1159/000530958. Epub 2023 May 12.

Al-Haj Husain N, Al-Haj Husain A, Grgic I, Kipar A, Molinero-Mourelle P, Stadlinger B, Özcan M, 2023, Effect of Cumulative Ionizing Radiation on Flexural Strength, Flexural Modulus, and Elasticity Modulus of Dentin in Unerupted Human Third Molars. Adv Radiat Oncol. 2022 Nov 23;8(2):101127. doi: 10.1016/j.adro.2022.101127. eCollection 2023 Mar-Apr.

Di Nitto C, Gilardoni E, Mock J, Nadal L, Weiss T, Weller M, Seehusen F, Libbra C, Puca E, Neri D, De Luca R, 2023, An Engineered IFNγ-Antibody Fusion Protein with Improved Tumor-Homing Properties. Pharmaceutics. 2023 Jan 22;15(2):377. doi: 10.3390/pharmaceutics15020377.

Avilla-Royo E, Seehusen F, Devaud YR, Monné Rodriguez JM, Strübing N, Weisskopf M, Messersmith PB, Vonzun L, Moehrlen U, Ehrbar M, Ochsenbein-Kölble N, 2022, In vivo Sealing of Fetoscopy-Induced Fetal Membrane Defects by Mussel Glue. Fetal Diagn Ther. 2022;49(11-12):518-527. doi: 10.1159/000528473. Epub 2023 Jan 12.

Sobecki M, Chen J, Krzywinska E, Nagarajan S, Fan Z, Nelius E, Monné Rodriguez JM, Seehusen F, Hussein A, Moschini G, Hajam EY, Kiran R, Gotthardt D, Debbache J, Badoual C, Sato T, Isagawa T, Takeda N, Tanchot C, Tartour E, Weber A, Werner S, Loffing J, Sommer L, Sexl V, Münz C, Feghali-Bostwick C, Pachera E, Distler O, Snedeker J, Jamora C, Stockmann C, 2022, Vaccination-based immunotherapy to target profibrotic cells in liver and lung. Cell Stem Cell. 2022 Oct 6;29(10):1459-1474.e9. doi: 10.1016/j.stem.2022.08.012. Epub 2022 Sep 15.

Leuthardt AS, Bayer J, Monné Rodríguez JM, Boyle CN, 2021, Influence of High Energy Diet and Polygenic Predisposition for Obesity on Postpartum Health in Rat Dams. Front Physiol​​​​​​​. 2022 Feb 10:12:772707. doi: 10.3389/fphys.2021.772707. eCollection 2021.

Perruzza L, Strati F, Raneri M, Li H, Gargari G, Rezzonico-Jost T, Palatella M, Kwee I, Morone D, Seehusen F, Sonego P, Donati C, Franceschi P, Macpherson AJ, Guglielmetti S, Greiff V, Grassi F, 2022, Apyrase-mediated amplification of secretory IgA promotes intestinal homeostasis. Cell Rep. 2022 Jul 19;40(3):111112. doi: 10.1016/j.celrep.2022.111112.

Ruiz-Serrano A, Boyle CN, Monné Rodríguez JM, Günter J, Jucht AE, Pfundstein S, Bapst AM, Lutz TA, Wenger RH, Scholz CC, 2022, The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism. Int J Mol Sci​​​​​​​. 2022 Jan 28;23(3):1536. doi: 10.3390/ijms23031536.

Chan T, Grisch-Chan HM, Schmierer P, Subotic U, Rimann N, Scherer T, Hetzel U, Bozza M, Harbottle R, Williams JA, Steblaj B, Ringer SK, Häberle J, Sidler X, Thöny B, 2022, Delivery of non-viral naked DNA vectors to liver in small weaned pigs by hydrodynamic retrograde intrabiliary injection. Mol Ther Methods Clin Dev​​​​​​​. 2022 Jan 19:24:268-279. doi: 10.1016/j.omtm.2022.01.006. eCollection 2022 Mar 10.

Ruiz-Serrano A, Monné Rodríguez JM, Günter J, Sherman SPM, Jucht AE, Fluechter P, Volkova YL, Pfundstein S, Pellegrini G, Wagner CA, Schneider C, Wenger RH, Scholz CC, 2021, OTUB1 regulates lung development, adult lung tissue homeostasis, and respiratory control. FASEB J. 2021 Dec;35(12):e22039. doi: 10.1096/fj.202100346R.

Millul J, Krudewig C, Zana A, Dakhel Plaza S, Puca E, Villa A, Neri D, Cazzamalli S, 2021. Immunotherapy with immunocytokines and PD-1 blockade enhances the anticancer activity of small molecule-drug conjugates targeting carbonic anhydrase IX. Mol Cancer Ther 20(3):512-522. doi: 10.1158/1535-7163.MCT-20-0361.

Kast F, Schwill M, Stüber JC, Pfundstein S, Nagy-Davidescu G, Rodríguez JMM, Seehusen F, Richter CP, Honegger A, Hartmann KP, Weber TG, Kroener F, Ernst P, Piehler J, Plückthun A, 2021, Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action. Nat Commun. 2021 Jun 18;12(1):3790. doi: 10.1038/s41467-021-23948-6.

Romero-Palomo F, Festag M, Lenz B, Schadt S, Brink A, Kipar A, Steinhuber B, Husser C, Koller E, Sewing S, Tessier Y, Dzygiel P, Fischer G, Winter M, Hetzel U, Mihatsch MJ, Braendli-Baiocco A, 2021. Safety, tissue distribution, and metabolism of LNA-containing antisense oligonucleotides in rats. Toxicol Pathol 49(6), 1174-1192. doi: 10.1177/01926233211011615.

Joekel DE, Nur S, Monné Rodriguez J, Kronenberg PA, Kipar A, LeibundGut-Landmann S, Deplazes P, 2021, Agranulocytosis leads to intestinal Echinococcus multilocularis oncosphere invasion and hepatic metacestode development in naturally resistant Wistar rats. Parasitology. 2021 Jan;148(1):53-62. doi: 10.1017/S0031182020002012. Epub 2020 Oct 22.

Meier D, Lodberg A, Gvozdenovic A, Pellegrini G, Neklyudova O, Born W, Fuchs B, Eijken M, M Botter S, 2021, Inhibition of the activin receptor signaling pathway: A novel intervention against osteosarcoma. Cancer Med. 2021 Jan;10(1):286-296. doi: 10.1002/cam4.3581.

Ferrari A, Giampietro C, Bachmann B, Bernardi L, Bezuidenhhout D, Ermanni P, Hopf R, Kitz S, Kress G, Loosli C, Marina V, Meboldt M, Pellegrini G, Poulikakos D, Rebholz M, Schmid Daners M, Schmidt T, Starck C, Stefopoulos G, Sündermann S, Thamsen B, Zilla P, Potapov E, Falk V, Mazza E, 2021, A Novel Hybrid Membrane VAD as First Step Toward Hemocompatible Blood Propulsion. Ann Biomed Eng. 2021 Feb;49(2):716-731. doi: 10.1007/s10439-020-02590-1. Epub 2020 Sep 8.

Blümich S, Zdimerova H, Münz C, Kipar A, Pellegrini G, 2021. Morphological and immunophenotypic features of human CD34+ hematopoietic stem cell-engrafted NSG mice. Vet Pathol 58(1), 161-180. doi: 10.1177/0300985820948822.

Pellegrini G, Williams D, Amadio D, Park BK, Kipar A, 2020. Morphological and mechanistic aspects of thiourea-induced acute lung injury and tolerance in the rat. Toxicol Pathol 48(6), 725-737.

Guzik P, Benešová M, Ratz M, Monné Rodríguez JM, Deberle LM, Schibli R, Müller C, 2021, Preclinical evaluation of 5-methyltetrahydrofolate-based radioconjugates-new perspectives for folate receptor-targeted radionuclide therapy. Eur J Nucl Med Mol Imaging. 2021 Apr;48(4):972-983. doi: 10.1007/s00259-020-04980-y. Epub 2020 Oct 15.

Kuo W, Le NA, Spingler B, Weger RH, Kipar A, Hetzel U, Schulz G, Müller B, Kurtuoglu V, 2020. Simultaneous three-dimensional vascular and tubular imaging of whole mouse kidneys with X-ray µCT. Microsc Microanal 26(4):731-740. doi: 10.1017/S1431927620001725.

Gomes de Almeida Schirmer B, Crucet M, Stivala S, Vucicevic G, da Silva Barcelos L, Vanhoutte PM, Pellegrini G, Camici GG, Seebeck P, Pfundstein S, Stein S, Paneni F, Lüscher TF, Simic B, 2020, The NO-donor MPC-1011 stimulates angiogenesis and arteriogenesis and improves hindlimb ischemia via a cGMP-dependent pathway involving VEGF and SDF-1α. Atherosclerosis. 2020 Jul:304:30-38. doi: 10.1016/j.atherosclerosis.2020.05.012. Epub 2020 May 30.

Puca E, De Luca R, Seehusen F, Rodriguez JMM, Neri D, 2020, Comparative evaluation of bolus and fractionated administration modalities for two antibody-cytokine fusions in immunocompetent tumor-bearing mice. J Control Release. 2020 Jan 10:317:282-290. doi: 10.1016/j.jconrel.2019.11.036. Epub 2019 Nov 29.

Terraneo N, Jacob F, Peitzsch C, Dubrovska A, Krudewig C, Huang YL, Heinzelmann-Schwarz V, Schibli R, Béhé M, Grünberg J, 2020. L1 cell adhesion molecule confers radioresistance to ovarian cancer and defines a new cancer stem cell population. Cancers (Basel) 12(1):217. doi: 10.1016/j.kint.2018.02.017.

Motta SE, Fioretta ES, Lintas V, Dijkman PE, Hilbe M, Frese L, Cesarovic N, Loerakker S, Baaijens FPT, Falk V, Hoerstrup SP, Emmert MY, 2020. Geometry influences inflammatory host cell response and remodeling in tissue-engineered heart valves in-vivo. Sci Rep 10(1):19882.

Perruzza L, Jaconi S, Lombardo G, Pinna D, Strati F, Morone D, Seehusen F, Hu Y, Bajoria S, Xiong J, Kumru OS, Joshi SB, Volkin DB, Piantanida R, Benigni F, Grassi F, Corti D, Pizzuto MS, 2020. Prophylactic Activity of Orally Administered FliD-Reactive Monoclonal SIgA Against Campylobacter Infection. Front Immunol. 11:1011.

Robotti F, Sterner I, Bottan S, Monné Rodríguez JM, Pellegrini G, Schmidt T, Falk V, Poulikakos D, Ferrari A, Starck C, 2020. Microengineered biosynthesized cellulose as anti-fibrotic in vivo protection for cardiac implantable electronic devices. Biomaterials 229:119583. doi: 10.1016/j.biomaterials.2019.119583.

Schorer M, Rakebrandt N, Littringer K, Hunziker A, Pallmer K, Kipar A, Stertz S, Oxenius A, Joller, N, 2020. TIGIT limits immune pathology during viral infections. Nat Commun 11(1):1288. doi: 10.1038/s41467-020-15025-1

Strandin T, Smura T, Ahola P, Aaltonen K, Sironen T, Hepojoki J, Eckerle I, Ulrich RG, Vapalahti O, Kipar A, Forbes K, 2020. Orthohantavirus isolated in reservoir host cells displays minimal genetic changes and retains wild-type infection properties. Viruses. 2020 Apr 17;12(4):E457. doi: 10.3390/v12040457.