Laboratory for Animal Model Pathology (LAMP)

The Laboratory for Animal Model Pathology (LAMP) has been established to assist research in relevant, generic areas of laboratory/experimental animal morphology and pathology.

a core research and service facility at the Vetsuisse Faculty, University of Zurich.

technical services and expertise to researchers at the University of Zurich and outside clients who undertake morphological studies as part of their work with animal models and/or laboratory animals.

Submisson Form LAMP

foster interdisciplinary research for optimal use of laboratory/experimental animals;

provide scientific support through laboratory animal health monitoring and disease diagnosis (diagnostic service);

provide veterinary pathology expertise for research projects involving animal work (on collaborative and service basis);

provide a timely and cost-effective technical service and expertise in relevant, generic areas of laboratory/experimental animal morphology and pathology;

train researchers in basic techniques to allow optimal in situ studies on experimental animals (in collaboration with the Institute of Laboratory Animal Science LAS/LTK, Vetsuisse Faculty, University of Zürich: www.ltk.uzh.ch).

Veterinary pathologists at LAMP are partners in various interdisciplinary research projects and lead their own laboratory animal research tracks. Find further information on our research site under Animal Models. For a list of selected recent publications, see below.

Pellegrini G, Siwowska K, Haller S, Antoine D, Schibli R, Kipar A, Mueller C. A short-term biological indicator for long-term kidney damage after radionuclide therapy in mice. Pharmaceuticals (Basel). 2017 Jun 21;10(2). pii: E57. doi: 10.3390/ph10020057.

Emmert MY, Wolint P, Jakab A, Sheehy SP, Pasqualini FS, Nguyen TDL, Hilbe M, Seifert B, Weber B, Brokopp CE, Macejovska D, Caliskan E, von Eckardstein A, Schwartlander R, Vogel V, Falk V, Parker KK, Gyöngyösi M, Hoerstrup SP, 2017. Safety and efficacy of cardiopoietic stem cells in the treatment of post-infarction left-ventricular dysfunction - from cardioprotection to functional repair in a translational pig infarction model. Biomaterials 122:48-62.

Akram KM, Moyo NA, Leeming GH, Bingle L, Jasim S, Hussain S, Schorlemmer A, Kipar A, Digard P, Tripp RA, Shotet RV, Bingle CD, Stewart JP, 2018. An innate defence peptide BPIFA1/SPLUNC1 restricts Influenza A virus infection. Mucosal Immunol 11(1), 71-81. doi: 10.1038/mi.2017.45.

Schmid AS, Hemmerle T, Pretto F, Kipar A, Neri D, 2018. Antibody-based targeted delivery of interleukin-4 synergizes with dexamethasone for the reduction of inflammation in arthritis. Rheumatology (Oxford) 57(4), 748-755.

Schmid M, Ernst P, Honegger A, Suomalainen M, Zimmermann M, Braun L, Stauffer S, Thom C, Dreier B, Eibauer M, Kipar A, Vogel V, Greber UF, Medalia O, Plückthun A, 2018. Adenovirus with shield and adapter increases tumor specificity and escapes liver and immune control. Nat Commun 9(1):450. doi: 10.1038/s41467-017-02707-6.

Pastor-Arroyo EM, Gehring N, Krudewig C, Costantino S, Bettoni C, Knöpfel T, Sabrautzki S, Lorenz-Depiereux B, Pastor J, Strom TM, Hrabě de Angelis M, Camici GG, Paneni F, Wagner CA, Rubio-Aliaga I, 2018. The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk. Kidney Int 94(1):49-59. doi: 10.3415/VCOT-15-08-0142.

Greco F, Wiegert S, Baumann P, Wellmann S, Pellegrini G, Cannizzaro V, 2019. Hyperoxia-induced lung structure-function relation, vessel rarefaction, and cardiac hypertrophy in an infant rat model. J Transl Med. 17(1):91. doi: 10.1186/s12967-019-1843-1.

Siwowska K, Guzik P, Domnanich KA, Monné Rodríguez JM, Bernhardt P, Ponsard B, Hasler R, Borgna F, Schibli R, Köster U, van der Meulen NP, Müller C, 2019. Therapeutic potential of 47 Sc in comparison to 177 Lu and 90 Y: preclinical investigations. Pharmaceutics 11(8):424. doi: 10.3390/pharmaceutics11080424.

Wolint P, Bopp A, Woloszyk A, Tian Y, Evrova O, Hilbe M, Giovanoli P, Calcagni M, Hoerstrup SP, Buschmann J, Emmert MY, 2019. Cellular self-assembly into 3D microtissues enhances the angiogenic activity and functional neovascularization capacity of human cardiopoietic stem cells. Angiogenesis 22(1):37-52.

Schorer M, Rakebrandt N, Littringer K, Hunziker A, Pallmer K, Kipar A, Stertz S, Oxenius A, Joller, N, 2020. TIGIT limits immune pathology during viral infections. Nat Commun 11(1):1288. doi: 10.1038/s41467-020-15025-1

Strandin T, Smura T, Ahola P, Aaltonen K, Sironen T, Hepojoki J, Eckerle I, Ulrich RG, Vapalahti O, Kipar A, Forbes K, 2020. Orthohantavirus isolated in reservoir host cells displays minimal genetic changes and retains wild-type infection properties. Viruses. 2020 Apr 17;12(4):E457. doi: 10.3390/v12040457.

Kuo W, Le NA, Spingler B, Weger RH, Kipar A, Hetzel U, Schulz G, Müller B, Kurtuoglu V, 2020. Simultaneous three-dimensional vascular and tubular imaging of whole mouse kidneys with X-ray µCT. Microsc Microanal 26(4):731-740. doi: 10.1017/S1431927620001725.

Pellegrini G, Williams D, Amadio D, Park BK, Kipar A, 2020. Morphological and mechanistic aspects of thiourea-induced acute lung injury and tolerance in the rat. Toxicol Pathol 48(6), 725-737.

Robotti F, Sterner I, Bottan S, Monné Rodríguez JM, Pellegrini G, Schmidt T, Falk V, Poulikakos D, Ferrari A, Starck C, 2020. Microengineered biosynthesized cellulose as anti-fibrotic in vivo protection for cardiac implantable electronic devices. Biomaterials 229:119583. doi: 10.1016/j.biomaterials.2019.119583.

Perruzza L, Jaconi S, Lombardo G, Pinna D, Strati F, Morone D, Seehusen F, Hu Y, Bajoria S, Xiong J, Kumru OS, Joshi SB, Volkin DB, Piantanida R, Benigni F, Grassi F, Corti D, Pizzuto MS, 2020. Prophylactic Activity of Orally Administered FliD-Reactive Monoclonal SIgA Against Campylobacter Infection. Front Immunol. 11:1011.

Motta SE, Fioretta ES, Lintas V, Dijkman PE, Hilbe M, Frese L, Cesarovic N, Loerakker S, Baaijens FPT, Falk V, Hoerstrup SP, Emmert MY, 2020. Geometry influences inflammatory host cell response and remodeling in tissue-engineered heart valves in-vivo. Sci Rep 10(1):19882.

Terraneo N, Jacob F, Peitzsch C, Dubrovska A, Krudewig C, Huang YL, Heinzelmann-Schwarz V, Schibli R, Béhé M, Grünberg J, 2020. L1 cell adhesion molecule confers radioresistance to ovarian cancer and defines a new cancer stem cell population. Cancers (Basel) 12(1):217. doi: 10.1016/j.kint.2018.02.017.

Blümich S, Zdimerova H, Münz C, Kipar A, Pellegrini G, 2021. Morphological and immunophenotypic features of human CD34+ hematopoietic stem cell-engrafted NSG mice. Vet Pathol 58(1), 161-180. doi: 10.1177/0300985820948822.

Millul J, Krudewig C, Zana A, Dakhel Plaza S, Puca E, Villa A, Neri D, Cazzamalli S, 2021. Immunotherapy with immunocytokines and PD-1 blockade enhances the anticancer activity of small molecule-drug conjugates targeting carbonic anhydrase IX. Mol Cancer Ther 20(3):512-522. doi: 10.1158/1535-7163.MCT-20-0361.

Romero-Palomo F, Festag M, Lenz B, Schadt S, Brink A, Kipar A, Steinhuber B, Husser C, Koller E, Sewing S, Tessier Y, Dzygiel P, Fischer G, Winter M, Hetzel U, Mihatsch MJ, Braendli-Baiocco A, 2021. Safety, tissue distribution, and metabolism of LNA-containing antisense oligonucleotides in rats. Toxicol Pathol 49(6), 1174-1192. doi: 10.1177/01926233211011615.